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UXT

GENERAL INFORMATION

Gene name

 UXT

Gene description

 Ubiquitously-expressed, prefoldin-like chaperone

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA058400
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA058400

GENE INFORMATION

Gene name

 UXT (HGNC Symbol)

Synonyms

 ART-27, STAP1

Description

 Ubiquitously-expressed, prefoldin-like chaperone (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 47651798 - 47659161

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126756 (version 83.38)

Entrez gene

 8409

UniProt

 Q9UBK9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBK9

Antibodypedia

 UXT antibodies

PROTEIN BROWSER
UXT-001
UXT-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UXT-001
ENSP00000327797
ENST00000333119
Q9UBK9 [Direct mapping]
Protein UXT
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000930 [gamma-tubulin complex]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0008017 [microtubule binding]
GO:0047497 [mitochondrion transport along microtubule]
GO:0048487 [beta-tubulin binding]
GO:0051297 [centrosome organization]
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 157 aa
18.2 kDa 		No 0
UXT-002
ENSP00000337393
ENST00000335890
A0A0C4DFR8 [Direct mapping]
Protein UXT; Ubiquitously-expressed transcript, isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
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 169 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.