Expression of KTN1 in cancer - Summary - The Human Protein Atlas

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KTN1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KTN1
Gene description	Kinectin 1 (kinesin receptor)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA003178 , HPA017876 , CAB015331
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003178	HPA017876	CAB015331

GENE INFORMATION
Gene name	KTN1 (HGNC Symbol)
Synonyms	CG1, KIAA0004
Description	Kinectin 1 (kinesin receptor) (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Chromosome	14
Cytoband	q22.3
Chromosome location (bp)	55559072 - 55701526
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126777 (version 83.38)
Entrez gene	3895
UniProt	Q86UP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UP2
Antibodypedia	KTN1 antibodies

PROTEIN BROWSER

KTN1-002	KTN1-003	KTN1-004	KTN1-005	KTN1-006	KTN1-007	KTN1-013	KTN1-014	KTN1-015	KTN1-018	KTN1-019	KTN1-021	KTN1-023	KTN1-201	KTN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KTN1-002 ENSP00000378725 ENST00000395314	Q86UP2 [Direct mapping] Kinectin A0A024R663 [Target identity:100%; Query identity:100%] Kinectin 1 (Kinesin receptor), isoform CRA_a; Kinectin 1 (Kinesin receptor), isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1357 aa 156.3 kDa	No	1
KTN1-003 ENSP00000378722 ENST00000395311	Q86UP2 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1306 aa 150.4 kDa	No	1
KTN1-004 ENSP00000391964 ENST00000438792	Q86UP2 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1300 aa 149.6 kDa	No	1
KTN1-005 ENSP00000378719 ENST00000395308	Q86UP2 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1306 aa 150.4 kDa	No	1
KTN1-006 ENSP00000452073 ENST00000554507	G3V4Y7 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	595 aa 68.9 kDa	No	0
KTN1-007 ENSP00000451698 ENST00000555573	B7Z6P3 [Direct mapping] Kinectin; cDNA FLJ55573, highly similar to Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	334 aa 38.9 kDa	No	0
KTN1-013 ENSP00000451641 ENST00000557267	G3V475 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] Show all	60 aa 7.3 kDa	No	1
KTN1-014 ENSP00000451878 ENST00000555498	G3V4L8 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0015031 [protein transport] GO:0019894 [kinesin binding] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	75 aa 9 kDa	No	1
KTN1-015 ENSP00000452459 ENST00000554567	G3V5Q0 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.8 kDa	No	0
KTN1-018 ENSP00000452445 ENST00000553624	G3V5P0 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	160 aa 18.5 kDa	No	0
KTN1-019 ENSP00000452337 ENST00000554890	G3V5G2 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	162 aa 18.7 kDa	No	0
KTN1-021 ENSP00000452205 ENST00000554570	H0YJV5 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	91 aa 10.8 kDa	No	0
KTN1-023 ENSP00000451876 ENST00000554294	H0YJP2 [Direct mapping] Kinectin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007018 [microtubule-based movement] GO:0019894 [kinesin binding] Show all	138 aa 15.6 kDa	No	0
KTN1-201 ENSP00000378720 ENST00000395309	Q86UP2 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1306 aa 150.4 kDa	No	1
KTN1-202 ENSP00000394992 ENST00000413890	Q86UP2 [Direct mapping] Kinectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0007018 [microtubule-based movement] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0044822 [poly(A) RNA binding] Show all	1306 aa 150.4 kDa	No	1

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The Human Protein Atlas project is funded
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