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DLGAP5

GENERAL INFORMATION

Gene name

 DLGAP5

Gene description

 Discs, large (Drosophila) homolog-associated protein 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA005546
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005546

GENE INFORMATION

Gene name

 DLGAP5 (HGNC Symbol)

Synonyms

 DLG1, DLG7, HURP, KIAA0008

Description

 Discs, large (Drosophila) homolog-associated protein 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q22.3

Chromosome location (bp)

 55148112 - 55191678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126787 (version 83.38)

Entrez gene

 9787

UniProt

 Q15398 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15398

Antibodypedia

 DLGAP5 antibodies

PROTEIN BROWSER
DLGAP5-001
DLGAP5-002
DLGAP5-004
DLGAP5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLGAP5-001
ENSP00000247191
ENST00000247191
Q15398 [Direct mapping]
Disks large-associated protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006470 [protein dephosphorylation]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0008283 [cell proliferation]
GO:0023052 [signaling]
GO:0031616 [spindle pole centrosome]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
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 846 aa
95.1 kDa 		No 0
DLGAP5-002
ENSP00000378815
ENST00000395425
Q15398 [Direct mapping]
Disks large-associated protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006470 [protein dephosphorylation]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0008283 [cell proliferation]
GO:0023052 [signaling]
GO:0031616 [spindle pole centrosome]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
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 842 aa
94.2 kDa 		No 0
DLGAP5-004
ENSP00000452168
ENST00000554067
G3V543 [Direct mapping]
Disks large-associated protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 111 aa
13.2 kDa 		No 0
DLGAP5-005
ENSP00000451747
ENST00000557645
G3V4E5 [Direct mapping]
Disks large-associated protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
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 234 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.