Expression of L3HYPDH in cancer - Summary - The Human Protein Atlas

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L3HYPDH

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	L3HYPDH
Gene description	L-3-hydroxyproline dehydratase (trans-)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA056694
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056694

GENE INFORMATION
Gene name	L3HYPDH (HGNC Symbol)
Synonyms	C14orf149, FLJ25436
Description	L-3-hydroxyproline dehydratase (trans-) (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	59460363 - 59484430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126790 (version 83.38)
Entrez gene	112849
UniProt	Q96EM0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96EM0
Antibodypedia	L3HYPDH antibodies

PROTEIN BROWSER

L3HYPDH-003	L3HYPDH-005	L3HYPDH-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
L3HYPDH-003 ENSP00000247194 ENST00000247194	Q96EM0 [Direct mapping] Trans-3-hydroxy-L-proline dehydratase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016836 [hydro-lyase activity] GO:0018112 [proline racemase activity] GO:0050346 [trans-L-3-hydroxyproline dehydratase activity] Show all	354 aa 38.1 kDa	No	0
L3HYPDH-005 ENSP00000431608 ENST00000487285	E9PKK7 [Direct mapping] Trans-3-hydroxy-L-proline dehydratase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0018112 [proline racemase activity] Show all	145 aa 15.6 kDa	No	0
L3HYPDH-007 ENSP00000423874 ENST00000481608	D6RC46 [Direct mapping] Trans-3-hydroxy-L-proline dehydratase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0018112 [proline racemase activity] Show all	142 aa 15.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.