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SGPP1

GENERAL INFORMATION

Gene name

 SGPP1

Gene description

 Sphingosine-1-phosphate phosphatase 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053149
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053149

GENE INFORMATION

Gene name

 SGPP1

Synonyms

Description

 Sphingosine-1-phosphate phosphatase 1 (HGNC Symbol)

Entrez gene summary

 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

Chromosome

 14

Cytoband

 q23.2

Chromosome location (bp)

 63684214 - 63728039

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126821 (version 83.38)

Entrez gene

 81537

UniProt

 Q9BX95 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BX95

Antibodypedia

 SGPP1 antibodies

PROTEIN BROWSER
SGPP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGPP1-001
ENSP00000247225
ENST00000247225
Q9BX95 [Direct mapping]
Sphingosine-1-phosphate phosphatase 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006665 [sphingolipid metabolic process]
GO:0006668 [sphinganine-1-phosphate metabolic process]
GO:0006670 [sphingosine metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0030148 [sphingolipid biosynthetic process]
GO:0042392 [sphingosine-1-phosphate phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
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 441 aa
49.1 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.