Expression of AIF1L in cancer - Summary

GENERAL INFORMATION
Gene name	AIF1L
Gene description	Allograft inflammatory factor 1-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, NTERA-2, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (kidney, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, most abundant in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA020522 , HPA056852
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA020522	HPA056852

GENE INFORMATION
Gene name	AIF1L (HGNC Symbol)
Synonyms	C9orf58, FLJ12783, IBA2
Description	Allograft inflammatory factor 1-like (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband
Chromosome location (bp)	131096476 - 131123152
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126878 (version 83.38)
Entrez gene	83543
UniProt	Q9BQI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQI0
Antibodypedia	AIF1L antibodies

PROTEIN BROWSER

AIF1L-001	AIF1L-003	AIF1L-004	AIF1L-005	AIF1L-006	AIF1L-010	AIF1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AIF1L-001 ENSP00000247291 ENST00000247291	Q9BQI0 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005884 [actin filament] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] GO:0032587 [ruffle membrane] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	150 aa 17.1 kDa	No	0
AIF1L-003 ENSP00000361376 ENST00000372302	Q9BQI0 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005884 [actin filament] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] GO:0032587 [ruffle membrane] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	142 aa 16.2 kDa	No	0
AIF1L-004 ENSP00000361374 ENST00000372300	Q9BQI0 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005884 [actin filament] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] GO:0032587 [ruffle membrane] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	102 aa 11.8 kDa	No	0
AIF1L-005 ENSP00000361371 ENST00000372297	Q5JUP1 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	46 aa 5.3 kDa	No	0
AIF1L-006 ENSP00000361372 ENST00000372298	Q5JUP3 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	97 aa 11.3 kDa	No	0
AIF1L-010 ENSP00000361375 ENST00000372301	A6PVM9 [Direct mapping] Allograft inflammatory factor 1-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	94 aa 10.5 kDa	No	0
AIF1L-201 ENSP00000361383 ENST00000372309	Q9BQI0 [Direct mapping] Allograft inflammatory factor 1-like Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005884 [actin filament] GO:0005925 [focal adhesion] GO:0015629 [actin cytoskeleton] GO:0032587 [ruffle membrane] GO:0043234 [protein complex] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	176 aa 20 kDa	No	0