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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MAP2K2
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MAP2K2

Gene description

Mitogen-activated protein kinase kinase 2

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA051993 , CAB003835
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PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (favourable), cervical cancer (favourable) and head and neck cancer (favourable).
Stomach cancer p<0.001
Cervical cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA051993
CAB003835

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers displayed weak to moderate cytoplasmic immunoreactivity. Several cases of hepatocellular carcinomas showed strong positivity. Additional membranous positivity was observed in a few cases. Most renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed moderate to strong cytoplasmic immunoreactivity. Several ovarian, lung, renal and liver cancers were weakly stained or negative.

GENE INFORMATION

Gene name

MAP2K2 (HGNC Symbol)

Synonyms

MEK2, PRKMK2

Description

Mitogen-activated protein kinase kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

4090321 - 4124129

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126934 (version 83.38)

Entrez gene

5605

UniProt

P36507 (UniProt - Evidence at protein level)

neXtProt

NX_P36507

Antibodypedia

MAP2K2 antibodies

PROTEIN BROWSER

MAP2K2-001
MAP2K2-010
MAP2K2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K2-001
ENSP00000262948
ENST00000262948
P36507 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   Phobius predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0001932 [regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010629 [negative regulation of gene expression]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030165 [PDZ domain binding]
GO:0030878 [thyroid gland development]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0032947 [protein complex scaffold]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048538 [thymus development]
GO:0048679 [regulation of axon regeneration]
GO:0050772 [positive regulation of axonogenesis]
GO:0060324 [face development]
GO:0060425 [lung morphogenesis]
GO:0060440 [trachea formation]
GO:0060502 [epithelial cell proliferation involved in lung morphogenesis]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090170 [regulation of Golgi inheritance]
GO:0097110 [scaffold protein binding]
GO:2000147 [positive regulation of cell motility]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
400 aa
44.4 kDa
No 0
MAP2K2-010
ENSP00000471763
ENST00000599021
M0R1B6 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
Show all
104 aa
11.6 kDa
No 0
MAP2K2-201
ENSP00000378336
ENST00000394867
G5E9C7 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 2; Mitogen-activated protein kinase kinase 2, isoform CRA_b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
303 aa
33.9 kDa
No 0

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