We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancers displayed weak to moderate cytoplasmic immunoreactivity. Several cases of hepatocellular carcinomas showed strong positivity. Additional membranous positivity was observed in a few cases. Most renal cancers were negative.
Most cancer cells showed moderate to strong cytoplasmic immunoreactivity. Several ovarian, lung, renal and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
MAP2K2 (HGNC Symbol)
Synonyms
MEK2, PRKMK2
Description
Mitogen-activated protein kinase kinase 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
P36507 [Direct mapping] Dual specificity mitogen-activated protein kinase kinase 2
Show all
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Phobius predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
M0R1B6 [Direct mapping] Dual-specificity mitogen-activated protein kinase kinase 2
Show all
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
G5E9C7 [Direct mapping] Dual-specificity mitogen-activated protein kinase kinase 2; Mitogen-activated protein kinase kinase 2, isoform CRA_b
Show all
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)