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Cell line enhanced (EFO-21, SCLC-21H, SK-BR-3, U-2 OS)
HPA (normal tissue):
Tissue enhanced (esophagus, small intestine)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Estimation of protein expression could not be performed. View primary data.
ANTIBODY IHC RELIABILITY
Data reliability description
RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Hepatcellular carcinomas and occasional cases of gastric and pancreatic cancers displayed moderate cytoplasmic immunoreactivity. The remaining cancer tissues were negative.
GENE INFORMATION
Gene name
EDN2 (HGNC Symbol)
Synonyms
ET2
Description
Endothelin 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]