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Basal cell carcinomas and cases of squamous cell carcinomas, non-Hodgkin's lymphomas, colorectal and urothelial cancers displayed moderate to strong nuclear positivity. Remaining cancers were negative.
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003334 [keratinocyte development] GO:0003382 [epithelial cell morphogenesis] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007409 [axonogenesis] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010468 [regulation of gene expression] GO:0010837 [regulation of keratinocyte proliferation] GO:0019216 [regulation of lipid metabolic process] GO:0021773 [striatal medium spiny neuron differentiation] GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain] GO:0021953 [central nervous system neuron differentiation] GO:0022008 [neurogenesis] GO:0031077 [post-embryonic camera-type eye development] GO:0033077 [T cell differentiation in thymus] GO:0033153 [T cell receptor V(D)J recombination] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043005 [neuron projection] GO:0043066 [negative regulation of apoptotic process] GO:0043368 [positive T cell selection] GO:0043565 [sequence-specific DNA binding] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0045664 [regulation of neuron differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046632 [alpha-beta T cell differentiation] GO:0046872 [metal ion binding] GO:0048538 [thymus development] GO:0071678 [olfactory bulb axon guidance]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007165 [signal transduction] GO:0022008 [neurogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)