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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BCL11B
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BCL11B

Gene description

B-cell CLL/lymphoma 11B (zinc finger protein)

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Tissue enhanced (lymph node, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in a subset of lymphoid cells, squamous epithelia, neurons and testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 1 antibody.
HPA049117
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

HPA049117

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Basal cell carcinomas and cases of squamous cell carcinomas, non-Hodgkin's lymphomas, colorectal and urothelial cancers displayed moderate to strong nuclear positivity. Remaining cancers were negative.

GENE INFORMATION

Gene name

BCL11B (HGNC Symbol)

Synonyms

CTIP-2, CTIP2, hRIT1-alpha, ZNF856B

Description

B-cell CLL/lymphoma 11B (zinc finger protein) (HGNC Symbol)

Entrez gene summary

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Chromosome

14

Cytoband

q32.2

Chromosome location (bp)

99169287 - 99271524

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127152 (version 83.38)

Entrez gene

64919

UniProt

Q9C0K0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C0K0

Antibodypedia

BCL11B antibodies

PROTEIN BROWSER

BCL11B-001
BCL11B-002
BCL11B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL11B-001
ENSP00000349723
ENST00000357195
Q9C0K0 [Direct mapping]
B-cell lymphoma/leukemia 11B
L8B7P7 [Target identity:100%; Query identity:100%]
ATL1-alpha zinc finger protein; B-cell CLL/lymphoma 11B (Zinc finger protein), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003334 [keratinocyte development]
GO:0003382 [epithelial cell morphogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008285 [negative regulation of cell proliferation]
GO:0009791 [post-embryonic development]
GO:0010468 [regulation of gene expression]
GO:0010837 [regulation of keratinocyte proliferation]
GO:0019216 [regulation of lipid metabolic process]
GO:0021773 [striatal medium spiny neuron differentiation]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0021953 [central nervous system neuron differentiation]
GO:0022008 [neurogenesis]
GO:0031077 [post-embryonic camera-type eye development]
GO:0033077 [T cell differentiation in thymus]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043368 [positive T cell selection]
GO:0043565 [sequence-specific DNA binding]
GO:0043588 [skin development]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045664 [regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0046872 [metal ion binding]
GO:0048538 [thymus development]
GO:0071678 [olfactory bulb axon guidance]
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894 aa
95.5 kDa
No 0
BCL11B-002
ENSP00000280435
ENST00000345514
Q9C0K0 [Direct mapping]
B-cell lymphoma/leukemia 11B
L8B567 [Target identity:100%; Query identity:100%]
ATL1-gamma zinc finger protein; B-cell CLL/lymphoma 11B (Zinc finger protein), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007165 [signal transduction]
GO:0022008 [neurogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
823 aa
88.5 kDa
No 0
BCL11B-003
ENSP00000387419
ENST00000443726
D3YTK1 [Direct mapping]
B-cell lymphoma/leukemia 11B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
700 aa
75.4 kDa
No 0

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