Expression of COX7C in cancer - Summary - The Human Protein Atlas

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COX7C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COX7C
Gene description	Cytochrome c oxidase subunit VIIc
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA046647
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046647

GENE INFORMATION
Gene name	COX7C
Synonyms
Description	Cytochrome c oxidase subunit VIIc (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	86617904 - 86620962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127184 (version 83.38)
Entrez gene	1350
UniProt	P15954 (UniProt - Evidence at protein level)
neXtProt	NX_P15954
Antibodypedia	COX7C antibodies

PROTEIN BROWSER

COX7C-001	COX7C-002	COX7C-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX7C-001 ENSP00000247655 ENST00000247655	P15954 [Direct mapping] Cytochrome c oxidase subunit 7C, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	63 aa 7.2 kDa	No	1
COX7C-002 ENSP00000425759 ENST00000509578	P15954 [Direct mapping] Cytochrome c oxidase subunit 7C, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	63 aa 7.2 kDa	No	1
COX7C-006 ENSP00000422012 ENST00000515763	D6R9Z7 [Direct mapping] Cytochrome c oxidase subunit 7C, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:1902600 [hydrogen ion transmembrane transport] Show all	56 aa 6.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.