Expression of ABHD8 in cancer - Summary - The Human Protein Atlas

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ABHD8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD8
Gene description	Abhydrolase domain containing 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (PC-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA037658
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and colorectal cancer (unfavourable).
Pancreatic cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037658

GENE INFORMATION
Gene name	ABHD8 (HGNC Symbol)
Synonyms	FLJ11743, MGC14280, MGC2512
Description	Abhydrolase domain containing 8 (HGNC Symbol)
Entrez gene summary	This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17292131 - 17310236
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127220 (version 83.38)
Entrez gene	79575
UniProt	Q96I13 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96I13
Antibodypedia	ABHD8 antibodies

PROTEIN BROWSER

ABHD8-001	ABHD8-003	ABHD8-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD8-001 ENSP00000247706 ENST00000247706	Q96I13 [Direct mapping] Abhydrolase domain-containing protein 8 B2C6G3 [Target identity:100%; Query identity:100%] Abhydrolase domain containing 8 Show all	THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	439 aa 47.3 kDa	No	0
ABHD8-003 ENSP00000468883 ENST00000593489	M0QX40 [Direct mapping] Abhydrolase domain-containing protein 8 Show all	Predicted intracellular proteins Show all		175 aa 18 kDa	No	0
ABHD8-004 ENSP00000470413 ENST00000594194	M0QZA8 [Direct mapping] Abhydrolase domain-containing protein 8 Show all	Predicted intracellular proteins Show all		130 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.