Expression of HRASLS in cancer - Summary - The Human Protein Atlas

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HRASLS

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HRASLS
Gene description	HRAS-like suppressor
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (PC-3, SCLC-21H, U-2 OS, U-251 MG)
HPA (normal tissue):	Group enriched (skeletal muscle, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA051179
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (favourable).
Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051179

GENE INFORMATION
Gene name	HRASLS (HGNC Symbol)
Synonyms	H-REV107, HRASLS1
Description	HRAS-like suppressor (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q29
Chromosome location (bp)	193241125 - 193277738
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000127252 (version 83.38)
Entrez gene	57110
UniProt
neXtProt
Antibodypedia	HRASLS antibodies

PROTEIN BROWSER

HRASLS-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRASLS-001 ENSP00000264735 ENST00000264735	X6R3D1 [Direct mapping] HRAS-like suppressor, isoform CRA_b; Phospholipid-metabolizing enzyme A-C1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		273 aa 30.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.