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RAP1B

GENERAL INFORMATION

Gene name

 RAP1B

Gene description

 RAP1B, member of RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 28
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RAP1B (HGNC Symbol)

Synonyms

 DKFZp586H0723, K-REV, RAL1B

Description

 RAP1B, member of RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

Chromosome

 12

Cytoband

 q15

Chromosome location (bp)

 68610839 - 68671901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127314 (version 83.38)

Entrez gene

 5908

UniProt

 P61224 (UniProt - Evidence at protein level)

neXtProt

 NX_P61224

Antibodypedia

 RAP1B antibodies

PROTEIN BROWSER
«
RAP1B-001
RAP1B-002
RAP1B-004
RAP1B-006
RAP1B-007
RAP1B-008
RAP1B-009
RAP1B-010
RAP1B-011
RAP1B-013
RAP1B-014
RAP1B-015
RAP1B-016
RAP1B-017
RAP1B-018
RAP1B-019
RAP1B-020
RAP1B-021
RAP1B-022
RAP1B-023
RAP1B-024
RAP1B-025
RAP1B-026
RAP1B-027
RAP1B-028
RAP1B-029
RAP1B-030
RAP1B-031
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAP1B-001
ENSP00000250559
ENST00000250559
P61224 [Direct mapping]
Ras-related protein Rap-1b
A0A024RB87 [Target identity:100%; Query identity:100%]
RAP1B, member of RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 184 aa
20.8 kDa 		No 0
RAP1B-002
ENSP00000377085
ENST00000393436
P61224 [Direct mapping]
Ras-related protein Rap-1b
A0A024RB87 [Target identity:100%; Query identity:100%]
RAP1B, member of RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 184 aa
20.8 kDa 		No 0
RAP1B-004
ENSP00000443851
ENST00000541216
F5H7Y6 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 179 aa
20.4 kDa 		No 0
RAP1B-006
ENSP00000439966
ENST00000537460
P61224 [Direct mapping]
Ras-related protein Rap-1b
A0A024RB87 [Target identity:100%; Query identity:100%]
RAP1B, member of RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 184 aa
20.8 kDa 		No 0
RAP1B-007
ENSP00000399986
ENST00000450214
P61224 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 142 aa
16 kDa 		No 0
RAP1B-008
ENSP00000368270
ENST00000378985
B7ZB78 [Direct mapping]
Ras-related protein Rap-1b; cDNA, FLJ79442, highly similar to Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 118 aa
13.5 kDa 		No 0
RAP1B-009
ENSP00000446318
ENST00000540209
P61224 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 165 aa
18.8 kDa 		No 0
RAP1B-010
ENSP00000444830
ENST00000539091
P61224 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 142 aa
16 kDa 		No 0
RAP1B-011
ENSP00000440014
ENST00000542145
P61224 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 137 aa
15.4 kDa 		No 0
RAP1B-013
ENSP00000401095
ENST00000425247
E7ESV4 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 157 aa
17.7 kDa 		No 0
RAP1B-014
ENSP00000445138
ENST00000541167
F5H491 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 93 aa
10.4 kDa 		No 0
RAP1B-015
ENSP00000444786
ENST00000538283
F5H500 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 101 aa
11.4 kDa 		No 0
RAP1B-016
ENSP00000390972
ENST00000422358
F8WBC0 [Direct mapping]
Ras-related protein Rap-1b
Show all
   TMHMM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 32 aa
3.5 kDa 		No 0
RAP1B-017
ENSP00000446027
ENST00000489473
F5H0S2 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 11 aa
1.3 kDa 		No 0
RAP1B-018
ENSP00000441275
ENST00000341355
P61224 [Direct mapping]
Ras-related protein Rap-1b
A0A024RB87 [Target identity:100%; Query identity:100%]
RAP1B, member of RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0032403 [protein complex binding]
GO:0032486 [Rap protein signal transduction]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:1901888 [regulation of cell junction assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 184 aa
20.8 kDa 		No 0
RAP1B-019
ENSP00000437415
ENST00000545270
F5H6R7 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 122 aa
13.8 kDa 		No 0
RAP1B-020
ENSP00000444467
ENST00000538980
F5GZG1 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 122 aa
13.9 kDa 		No 0
RAP1B-021
ENSP00000445090
ENST00000543393
B7ZB78 [Direct mapping]
Ras-related protein Rap-1b; cDNA, FLJ79442, highly similar to Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 118 aa
13.5 kDa 		No 0
RAP1B-022
ENSP00000438088
ENST00000542018
F5H0B7 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 98 aa
11 kDa 		No 0
RAP1B-023
ENSP00000444060
ENST00000453560
F5H004 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 127 aa
14.3 kDa 		No 0
RAP1B-024
ENSP00000441952
ENST00000534899
F5GWU8 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 87 aa
9.7 kDa 		No 0
RAP1B-025
ENSP00000440466
ENST00000540781
F5GX62 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 139 aa
15.7 kDa 		No 0
RAP1B-026
ENSP00000443775
ENST00000535492
F5H823 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 103 aa
11.9 kDa 		No 0
RAP1B-027
ENSP00000444924
ENST00000485252
F5H4H0 [Direct mapping]
Ras-related protein Rap-1b
Show all
   TMHMM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 48 aa
5.4 kDa 		No 0
RAP1B-028
ENSP00000445977
ENST00000541386
F5H0S2 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 11 aa
1.3 kDa 		No 0
RAP1B-029
ENSP00000440635
ENST00000538877
F5GYH7 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 53 aa
6 kDa 		No 0
RAP1B-030
ENSP00000440708
ENST00000543697
F5GYB5 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 136 aa
15.5 kDa 		No 0
RAP1B-031
ENSP00000438311
ENST00000545720
F5H077 [Direct mapping]
Ras-related protein Rap-1b
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 85 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.