Cell atlas - PTPRB - The Human Protein Atlas

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PTPRB

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Plasma membrane
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	PTPRB
Gene description	Protein tyrosine phosphatase, receptor type, B
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cell junctions & vesicles.
RNA cell category	Cell line enhanced (TIME, HUVEC TERT2, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Vesicles (approved), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA067868
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, HUVEC TERT2, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cell junctions & vesicles.

Main location

Plasma membrane (approved)

Additional location

Vesicles (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067868	A-431	Vesicles
	HPA067868	A-431	Plasma membrane
	HPA067868	HaCaT	Cell Junctions
	HPA067868	U-2 OS	Vesicles
	HPA067868	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	PTPRB (HGNC Symbol)
Synonyms	PTPB
Description	Protein tyrosine phosphatase, receptor type, B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	70515866 - 70637440
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127329 (version 83.38)
Entrez gene	5787
UniProt	P23467 (UniProt - Evidence at protein level)
neXtProt	NX_P23467
Antibodypedia	PTPRB antibodies

PROTEIN BROWSER

PTPRB-001	PTPRB-003	PTPRB-004	PTPRB-006	PTPRB-007	PTPRB-008	PTPRB-009	PTPRB-010	PTPRB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRB-001 ENSP00000334928 ENST00000334414	P23467 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043235 [receptor complex] Show all	2215 aa 249.1 kDa	No	1
PTPRB-003 ENSP00000448058 ENST00000550358	F8VU56 [Direct mapping] Protein-tyrosine-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	2127 aa 239.6 kDa	No	1
PTPRB-004 ENSP00000448349 ENST00000551525	F8VSD5 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1583 aa 176.6 kDa	No	0
PTPRB-006 ENSP00000446982 ENST00000548122	Q6ZR19 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta; cDNA FLJ46721 fis, clone TRACH3018524, highly similar to Protein-tyrosine phosphatase beta (EC 3.1.3.48) Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1407 aa 157 kDa	No	0
PTPRB-007 ENSP00000261266 ENST00000261266	P23467 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043235 [receptor complex] Show all	1997 aa 224.3 kDa	Yes	1
PTPRB-008 ENSP00000438927 ENST00000538708	P23467 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043235 [receptor complex] Show all	1907 aa 214.5 kDa	Yes	1
PTPRB-009 ENSP00000447302 ENST00000550857	P23467 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043235 [receptor complex] Show all	1907 aa 214.2 kDa	Yes	1
PTPRB-010 ENSP00000446934 ENST00000547715	H0YHE8 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	103 aa 11.2 kDa	Yes	0
PTPRB-201 ENSP00000393028 ENST00000451516	J3QT52 [Direct mapping] Receptor-type tyrosine-protein phosphatase beta Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	919 aa 102.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.