Cell atlas - DYRK2 - The Human Protein Atlas

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DYRK2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DYRK2
Gene description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA027230 , HPA056902
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027230	A-431	Nucleoplasm
	HPA027230	A-431	Cytosol
	HPA027230	U-2 OS	Nucleoplasm
	HPA027230	U-2 OS	Cytosol
	HPA027230	U-251 MG	Nucleoplasm
	HPA027230	U-251 MG	Cytosol
	HPA056902	A-431	Nucleoplasm
	HPA056902	U-2 OS	Nucleus
	HPA056902	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	DYRK2
Synonyms
Description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (HGNC Symbol)
Entrez gene summary	DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	67648338 - 67665406
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127334 (version 83.38)
Entrez gene	8445
UniProt	Q92630 (UniProt - Evidence at protein level)
neXtProt	NX_Q92630
Antibodypedia	DYRK2 antibodies

PROTEIN BROWSER

DYRK2-001	DYRK2-002	DYRK2-003	DYRK2-005	DYRK2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DYRK2-001 ENSP00000342105 ENST00000344096	Q92630 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007224 [smoothened signaling pathway] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030145 [manganese ion binding] GO:0030529 [ribonucleoprotein complex] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043130 [ubiquitin binding] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0051534 [negative regulation of NFAT protein import into nucleus] Show all	601 aa 66.7 kDa	No	0
DYRK2-002 ENSP00000377186 ENST00000393555	Q92630 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007224 [smoothened signaling pathway] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030145 [manganese ion binding] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043130 [ubiquitin binding] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0051534 [negative regulation of NFAT protein import into nucleus] Show all	528 aa 59.7 kDa	No	0
DYRK2-003 ENSP00000440839 ENST00000543747	F5GXG1 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 2 Show all	Predicted intracellular proteins Show all		156 aa 17.4 kDa	No	0
DYRK2-005 ENSP00000324733 ENST00000319833	A0A0A0MR56 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 2 Show all	Predicted intracellular proteins Show all		94 aa 10.4 kDa	No	0
DYRK2-006 ENSP00000443314 ENST00000542503	F5H5L5 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	167 aa 18.9 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.