Expression of CRYGN in cancer - Summary - The Human Protein Atlas

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CRYGN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRYGN
Gene description	Crystallin, gamma N
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (seminal vesicle, thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA050788
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050788

GENE INFORMATION
Gene name	CRYGN
Synonyms
Description	Crystallin, gamma N (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151428835 - 151440813
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000127377 (version 83.38)
Entrez gene	155051
UniProt	Q8WXF5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WXF5
Antibodypedia	CRYGN antibodies

PROTEIN BROWSER

CRYGN-001	CRYGN-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYGN-001 ENSP00000338613 ENST00000337323	Q8WXF5 [Direct mapping] Gamma-crystallin N A0A090N8I5 [Target identity:100%; Query identity:100%] Crystallin, gamma N Show all	Predicted intracellular proteins Show all		182 aa 20.6 kDa	No	0
CRYGN-003 ENSP00000420157 ENST00000491928	Q8WXF5 [Direct mapping] Gamma-crystallin N Show all	Predicted intracellular proteins Show all		125 aa 14.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.