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Cancer tissues showed weak to moderate nuclear and cytoplasmic staining. Several cases of colorectal cancers displayed moderate cytoplasmic, membranous and nuclear staining.
GENE INFORMATION
Gene name
KLF2 (HGNC Symbol)
Synonyms
LKLF
Description
Kruppel-like factor 2 (HGNC Symbol)
Entrez gene summary
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]