Expression of UQCR11 in cancer - Summary - The Human Protein Atlas

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UQCR11

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	UQCR11
Gene description	Ubiquinol-cytochrome c reductase, complex III subunit XI
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (favourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	UQCR11 (HGNC Symbol)
Synonyms	QCR10, UQCR
Description	Ubiquinol-cytochrome c reductase, complex III subunit XI (HGNC Symbol)
Entrez gene summary	This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1597172 - 1605490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127540 (version 83.38)
Entrez gene	10975
UniProt	O14957 (UniProt - Inferred from homology)
neXtProt	NX_O14957
Antibodypedia	UQCR11 antibodies

PROTEIN BROWSER

UQCR11-001	UQCR11-004	UQCR11-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UQCR11-001 ENSP00000467262 ENST00000591899	O14957 [Direct mapping] Cytochrome b-c1 complex subunit 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0008121 [ubiquinol-cytochrome-c reductase activity] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070469 [respiratory chain] GO:1902600 [hydrogen ion transmembrane transport] Show all	56 aa 6.6 kDa	No	1
UQCR11-004 ENSP00000466420 ENST00000585671	O14957 [Direct mapping] Cytochrome b-c1 complex subunit 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0008121 [ubiquinol-cytochrome-c reductase activity] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070469 [respiratory chain] GO:1902600 [hydrogen ion transmembrane transport] Show all	56 aa 6.6 kDa	No	1
UQCR11-005 ENSP00000467555 ENST00000589880	O14957 [Direct mapping] Cytochrome b-c1 complex subunit 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0008121 [ubiquinol-cytochrome-c reductase activity] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070469 [respiratory chain] GO:1902600 [hydrogen ion transmembrane transport] Show all	56 aa 6.6 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.