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PKMYT1

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GENERAL INFORMATION

Gene name

 PKMYT1

Gene description

 Protein kinase, membrane associated tyrosine/threonine 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleus & nucleoli.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

Additional location

 In addition localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA068860
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleus & nucleoli.

Main location

 Golgi apparatus (supported)

Additional location

 Nucleus (approved), Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA068860 HaCaT Nucleoli
Golgi apparatus
HPA068860 MCF7 Nucleus
Nucleoli
Golgi apparatus
HPA068860 U-2 OS Nucleoli
Golgi apparatus

GENE INFORMATION

Gene name

 PKMYT1 (HGNC Symbol)

Synonyms

 MYT1, PPP1R126

Description

 Protein kinase, membrane associated tyrosine/threonine 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2968024 - 2980539

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127564 (version 83.38)

Entrez gene

 9088

UniProt

 Q99640 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99640

Antibodypedia

 PKMYT1 antibodies

PROTEIN BROWSER
«
PKMYT1-001
PKMYT1-002
PKMYT1-003
PKMYT1-004
PKMYT1-007
PKMYT1-008
PKMYT1-012
PKMYT1-014
PKMYT1-015
PKMYT1-017
PKMYT1-018
PKMYT1-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKMYT1-001
ENSP00000262300
ENST00000262300
Q99640 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
Show all
 499 aa
54.5 kDa 		No 0
PKMYT1-002
ENSP00000458943
ENST00000574385
Q99640 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
Show all
 490 aa
53.5 kDa 		No 0
PKMYT1-003
ENSP00000459123
ENST00000573944
Q99640 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
Show all
 490 aa
53.5 kDa 		No 0
PKMYT1-004
ENSP00000392855
ENST00000431515
B4DZM6 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; cDNA FLJ61000, highly similar to Membrane-associated tyrosine- andthreonine-specific cdc2-inhibitory kinase (EC 2.7.11.1)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 568 aa
61.7 kDa 		No 1
PKMYT1-007
ENSP00000460868
ENST00000574730
Q99640 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
Show all
 430 aa
47.3 kDa 		No 0
PKMYT1-008
ENSP00000397739
ENST00000440027
Q99640 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0010923 [negative regulation of phosphatase activity]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
Show all
 480 aa
52.1 kDa 		No 0
PKMYT1-012
ENSP00000461330
ENST00000575632
I3L4K3 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 169 aa
18.8 kDa 		No 0
PKMYT1-014
ENSP00000458545
ENST00000576268
I3L136 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 275 aa
30.3 kDa 		No 0
PKMYT1-015
ENSP00000458842
ENST00000572059
I3L1H7 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 147 aa
16.4 kDa 		No 0
PKMYT1-017
ENSP00000460598
ENST00000574415
I3L3P0 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 215 aa
24.1 kDa 		No 0
PKMYT1-018
ENSP00000461628
ENST00000572619
I3L4Y0 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.5 kDa 		No 0
PKMYT1-022
ENSP00000459880
ENST00000575040
I3L2S4 [Direct mapping]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
5.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.