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FBXL16

GENERAL INFORMATION

Gene name

 FBXL16

Gene description

 F-box and leucine-rich repeat protein 16

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, cerebral cortex, hippocampus)
FANTOM5:Tissue enhanced (brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039504 , HPA056354
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, caudate, hippocampus)

GENE INFORMATION

Gene name

 FBXL16 (HGNC Symbol)

Synonyms

 C16orf22, Fbl16, MGC33974

Description

 F-box and leucine-rich repeat protein 16 (HGNC Symbol)

Entrez gene summary

 Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 692498 - 705829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127585 (version 83.38)

Entrez gene

 146330

UniProt

 Q8N461 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N461

Antibodypedia

 FBXL16 antibodies

PROTEIN BROWSER
FBXL16-001
FBXL16-002
FBXL16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXL16-001
ENSP00000380746
ENST00000397621
Q8N461 [Direct mapping]
F-box/LRR-repeat protein 16
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
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 479 aa
51.7 kDa 		No 0
FBXL16-002
ENSP00000455217
ENST00000562563
Q8N461 [Direct mapping]
F-box/LRR-repeat protein 16
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Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 267 aa
29.4 kDa 		No 0
FBXL16-201
ENSP00000318674
ENST00000324361
Q8N461 [Direct mapping]
F-box/LRR-repeat protein 16
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 479 aa
51.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.