Expression of GNG13 in cancer - Summary

GENERAL INFORMATION
Gene name	GNG13
Gene description	Guanine nucleotide binding protein (G protein), gamma 13
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, HEK93, MCF7)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in Purkinje cells of cerebellum, including a subset of cells in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA046272
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046272

GENE INFORMATION
Gene name	GNG13 (HGNC Symbol)
Synonyms	G(gamma)13, h2-35
Description	Guanine nucleotide binding protein (G protein), gamma 13 (HGNC Symbol)
Entrez gene summary	Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	798041 - 800733
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127588 (version 83.38)
Entrez gene	51764
UniProt	Q9P2W3 (UniProt - Inferred from homology)
neXtProt	NX_Q9P2W3
Antibodypedia	GNG13 antibodies

PROTEIN BROWSER

GNG13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNG13-001 ENSP00000248150 ENST00000248150	Q9P2W3 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0030425 [dendrite] GO:0031681 [G-protein beta-subunit binding] GO:0044281 [small molecule metabolic process] GO:0050909 [sensory perception of taste] GO:0071377 [cellular response to glucagon stimulus] Show all	67 aa 7.9 kDa	No	0