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SMARCA4

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GENERAL INFORMATION

Gene name

 SMARCA4

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB004208
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004208 A-431 Nucleoplasm
CAB004208 U-2 OS Nucleoplasm
CAB004208 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 SMARCA4 (HGNC Symbol)

Synonyms

 BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10961001 - 11065395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127616 (version 83.38)

Entrez gene

 6597

UniProt

 P51532 (UniProt - Evidence at protein level)

neXtProt

 NX_P51532

Antibodypedia

 SMARCA4 antibodies

PROTEIN BROWSER
SMARCA4-001
SMARCA4-002
SMARCA4-003
SMARCA4-004
SMARCA4-005
SMARCA4-007
SMARCA4-015
SMARCA4-018
SMARCA4-201
SMARCA4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCA4-001
ENSP00000343896
ENST00000344626
P51532 [Direct mapping]
Transcription activator BRG1
A7E2E1 [Target identity:100%; Query identity:100%]
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1647 aa
184.6 kDa 		No 0
SMARCA4-002
ENSP00000466963
ENST00000590574
P51532 [Direct mapping]
Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1614 aa
181.3 kDa 		No 0
SMARCA4-003
ENSP00000392837
ENST00000444061
P51532 [Direct mapping]
Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1613 aa
181.3 kDa 		No 0
SMARCA4-004
ENSP00000464778
ENST00000589677
P51532 [Direct mapping]
Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1616 aa
181.6 kDa 		No 0
SMARCA4-005
ENSP00000445036
ENST00000541122
P51532 [Direct mapping]
Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1617 aa
181.7 kDa 		No 0
SMARCA4-007
ENSP00000395654
ENST00000429416
P51532 [Direct mapping]
Transcription activator BRG1
A7E2E1 [Target identity:100%; Query identity:100%]
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0002039 [p53 binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007286 [spermatid development]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0016020 [membrane]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030957 [Tat protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0032403 [protein complex binding]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043923 [positive regulation by host of viral transcription]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070182 [DNA polymerase binding]
GO:0070577 [lysine-acetylated histone binding]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 1647 aa
184.6 kDa 		No 0
SMARCA4-015
ENSP00000467796
ENST00000586985
K7EQF0 [Direct mapping]
Transcription activator BRG1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 113 aa
12.6 kDa 		No 0
SMARCA4-018
ENSP00000467200
ENST00000592158
K7EP28 [Direct mapping]
Transcription activator BRG1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
Show all
 136 aa
15.7 kDa 		No 0
SMARCA4-201
ENSP00000414727
ENST00000413806
A0A0A0MT49 [Direct mapping]
Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016887 [ATPase activity]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
Show all
 1681 aa
188.9 kDa 		No 0
SMARCA4-202
ENSP00000397783
ENST00000450717
Q9HBD4 [Direct mapping]
SMARCA4 isoform 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_c; Transcription activator BRG1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016887 [ATPase activity]
GO:0042393 [histone binding]
GO:0043044 [ATP-dependent chromatin remodeling]
Show all
 1679 aa
188.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.