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IL17B

GENERAL INFORMATION

Gene name

 IL17B

Gene description

 Interleukin 17B

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Tissue enhanced (breast)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA042441
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042441

GENE INFORMATION

Gene name

 IL17B (HGNC Symbol)

Synonyms

 IL-17B, IL-20, MGC138900, MGC138901, NIRF, ZCYTO7

Description

 Interleukin 17B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 149371324 - 149404202

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127743 (version 83.38)

Entrez gene

 27190

UniProt

 Q9UHF5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UHF5

Antibodypedia

 IL17B antibodies

PROTEIN BROWSER
IL17B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL17B-001
ENSP00000261796
ENST00000261796
Q9UHF5 [Direct mapping]
Interleukin-17B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
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GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
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 180 aa
20.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.