Expression of EMC6 in cancer - Summary - The Human Protein Atlas

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EMC6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EMC6
Gene description	ER membrane protein complex subunit 6
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA062681
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and cervical cancer (unfavourable).
Lung cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062681

GENE INFORMATION
Gene name	EMC6 (HGNC Symbol)
Synonyms	MGC2963, TMEM93
Description	ER membrane protein complex subunit 6 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3668815 - 3669668
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127774 (version 83.38)
Entrez gene	83460
UniProt	Q9BV81 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV81
Antibodypedia	EMC6 antibodies

PROTEIN BROWSER

EMC6-001	EMC6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMC6-001 ENSP00000248378 ENST00000248378	Q9BV81 [Direct mapping] ER membrane protein complex subunit 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000045 [autophagosome assembly] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034975 [protein folding in endoplasmic reticulum] GO:0072546 [ER membrane protein complex] GO:0097631 [integral component of omegasome membrane] Show all	110 aa 12 kDa	No	2
EMC6-002 ENSP00000380322 ENST00000397133	Q9BV81 [Direct mapping] ER membrane protein complex subunit 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000045 [autophagosome assembly] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034975 [protein folding in endoplasmic reticulum] GO:0072546 [ER membrane protein complex] GO:0097631 [integral component of omegasome membrane] Show all	110 aa 12 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.