Expression of METTL16 in cancer - Summary - The Human Protein Atlas

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METTL16

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	METTL16
Gene description	Methyltransferase like 16
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA020352
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020352

GENE INFORMATION
Gene name	METTL16 (HGNC Symbol)
Synonyms	METT10D, MGC3329
Description	Methyltransferase like 16 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2405562 - 2511891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127804 (version 83.38)
Entrez gene	79066
UniProt	Q86W50 (UniProt - Evidence at protein level)
neXtProt	NX_Q86W50
Antibodypedia	METTL16 antibodies

PROTEIN BROWSER

METTL16-001	METTL16-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METTL16-001 ENSP00000263092 ENST00000263092	Q86W50 [Direct mapping] Methyltransferase-like protein 16 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008168 [methyltransferase activity] GO:0044822 [poly(A) RNA binding] GO:0052907 [23S rRNA (adenine(1618)-N(6))-methyltransferase activity] GO:0070475 [rRNA base methylation] Show all	562 aa 63.6 kDa	No	0
METTL16-008 ENSP00000461546 ENST00000576976	I3L4V1 [Direct mapping] Methyltransferase-like protein 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008168 [methyltransferase activity] GO:0052907 [23S rRNA (adenine(1618)-N(6))-methyltransferase activity] GO:0070475 [rRNA base methylation] Show all	148 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.