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VIL1

GENERAL INFORMATION

Gene name

 VIL1

Gene description

 Villin 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Group enriched (CACO-2, Hep G2)
HPA (normal tissue):Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression of cytoplasm and luminal membranes in cells of the gastrointestinal tract, gallbladder and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA006884 , HPA006885 , CAB002452
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006884
HPA006885
CAB002452

GENE INFORMATION

Gene name

 VIL1 (HGNC Symbol)

Synonyms

 D2S1471, VIL

Description

 Villin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218419092 - 218453295

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127831 (version 83.38)

Entrez gene

 7429

UniProt

 P09327 (UniProt - Evidence at protein level)

neXtProt

 NX_P09327

Antibodypedia

 VIL1 antibodies

PROTEIN BROWSER
VIL1-001
VIL1-002
VIL1-003
VIL1-004
VIL1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VIL1-001
ENSP00000248444
ENST00000248444
P09327 [Direct mapping]
Villin-1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0001951 [intestinal D-glucose absorption]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0006461 [protein complex assembly]
GO:0007010 [cytoskeleton organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0030855 [epithelial cell differentiation]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0032432 [actin filament bundle]
GO:0032433 [filopodium tip]
GO:0032532 [regulation of microvillus length]
GO:0035727 [lysophosphatidic acid binding]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051125 [regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061041 [regulation of wound healing]
GO:0070062 [extracellular exosome]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902896 [terminal web assembly]
GO:2000392 [regulation of lamellipodium morphogenesis]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 827 aa
92.7 kDa 		No 0
VIL1-002
ENSP00000375962
ENST00000392114
B4DV78 [Direct mapping]
Villin-1; cDNA FLJ57609, highly similar to Villin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0007010 [cytoskeleton organization]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051693 [actin filament capping]
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 516 aa
58 kDa 		No 0
VIL1-003
ENSP00000409270
ENST00000440053
P09327 [Direct mapping]
Villin-1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005902 [microvillus]
GO:0005903 [brush border]
GO:0006461 [protein complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009617 [response to bacterium]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030042 [actin filament depolymerization]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0030836 [positive regulation of actin filament depolymerization]
GO:0030855 [epithelial cell differentiation]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0032432 [actin filament bundle]
GO:0032433 [filopodium tip]
GO:0035727 [lysophosphatidic acid binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051125 [regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061041 [regulation of wound healing]
GO:0070062 [extracellular exosome]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:2000392 [regulation of lamellipodium morphogenesis]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 421 aa
46.6 kDa 		No 0
VIL1-004
ENSP00000412657
ENST00000454069
C9J2B5 [Direct mapping]
Villin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051693 [actin filament capping]
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 158 aa
17.7 kDa 		No 0
VIL1-005
ENSP00000394030
ENST00000419986
H7C0B6 [Direct mapping]
Villin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0051693 [actin filament capping]
Show all
 213 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.