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RNF6

GENERAL INFORMATION

Gene name

 RNF6

Gene description

 Ring finger protein (C3H2C3 type) 6

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA039343 , HPA040048
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039343
HPA040048

GENE INFORMATION

Gene name

 RNF6 (HGNC Symbol)

Synonyms

 DKFZp686P0776

Description

 Ring finger protein (C3H2C3 type) 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.13

Chromosome location (bp)

 26132115 - 26222493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127870 (version 83.38)

Entrez gene

 6049

UniProt

 Q9Y252 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y252

Antibodypedia

 RNF6 antibodies

PROTEIN BROWSER
RNF6-001
RNF6-002
RNF6-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF6-001
ENSP00000342121
ENST00000346166
Q9Y252 [Direct mapping]
E3 ubiquitin-protein ligase RNF6
A0A024RDP2 [Target identity:100%; Query identity:100%]
Ring finger protein (C3H2C3 type) 6, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030424 [axon]
GO:0030517 [negative regulation of axon extension]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044314 [protein K27-linked ubiquitination]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070936 [protein K48-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
Show all
 685 aa
78.1 kDa 		No 0
RNF6-002
ENSP00000370982
ENST00000381570
Q9Y252 [Direct mapping]
E3 ubiquitin-protein ligase RNF6
A0A024RDP2 [Target identity:100%; Query identity:100%]
Ring finger protein (C3H2C3 type) 6, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030424 [axon]
GO:0030517 [negative regulation of axon extension]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044314 [protein K27-linked ubiquitination]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070936 [protein K48-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
Show all
 685 aa
78.1 kDa 		No 0
RNF6-006
ENSP00000371000
ENST00000381588
Q9Y252 [Direct mapping]
E3 ubiquitin-protein ligase RNF6
A0A024RDP2 [Target identity:100%; Query identity:100%]
Ring finger protein (C3H2C3 type) 6, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016874 [ligase activity]
GO:0030424 [axon]
GO:0030517 [negative regulation of axon extension]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044314 [protein K27-linked ubiquitination]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
Show all
 685 aa
78.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.