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GNG11

GENERAL INFORMATION

Gene name

 GNG11

Gene description

 Guanine nucleotide binding protein (G protein), gamma 11

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, HUVEC TERT2, U-87 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA045255
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA045255

GENE INFORMATION

Gene name

 GNG11 (HGNC Symbol)

Synonyms

 GNGT11

Description

 Guanine nucleotide binding protein (G protein), gamma 11 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 93921699 - 93928610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127920 (version 83.38)

Entrez gene

 2791

UniProt

 P61952 (UniProt - Evidence at protein level)

neXtProt

 NX_P61952

Antibodypedia

 GNG11 antibodies

PROTEIN BROWSER
GNG11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG11-001
ENSP00000248564
ENST00000248564
P61952 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Q53Y01 [Target identity:100%; Query identity:100%]
Guanine nucleotide-binding protein subunit gamma
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0044281 [small molecule metabolic process]
GO:0071377 [cellular response to glucagon stimulus]
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 73 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.