Expression of POR in cancer - Summary - The Human Protein Atlas

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POR

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	POR
Gene description	P450 (cytochrome) oxidoreductase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA010136 , CAB004372
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010136	CAB004372

GENE INFORMATION
Gene name	POR (HGNC Symbol)
Synonyms	CYPOR, FLJ26468
Description	P450 (cytochrome) oxidoreductase (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	75899200 - 75986855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127948 (version 83.38)
Entrez gene	5447
UniProt	P16435 (UniProt - Evidence at protein level)
neXtProt	NX_P16435
Antibodypedia	POR antibodies

PROTEIN BROWSER

POR-001	POR-002	POR-003	POR-004	POR-006	POR-009	POR-014	POR-015	POR-017	POR-018	POR-019	POR-020	POR-021	POR-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POR-001 ENSP00000419970 ENST00000461988	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0007584 [response to nutrient] GO:0008941 [nitric oxide dioxygenase activity] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071371 [cellular response to gonadotropin stimulus] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090181 [regulation of cholesterol metabolic process] GO:0090346 [cellular organofluorine metabolic process] Show all	680 aa 77 kDa	No	1
POR-002 ENSP00000409238 ENST00000412521	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	146 aa 16.4 kDa	No	1
POR-003 ENSP00000399327 ENST00000414186	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	172 aa 19.3 kDa	No	1
POR-004 ENSP00000389719 ENST00000418341	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	62 aa 7.1 kDa	No	1
POR-006 ENSP00000403494 ENST00000439297	C9JDE2 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process] Show all	54 aa 6.1 kDa	No	0
POR-009 ENSP00000378355 ENST00000394893	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	633 aa 71.6 kDa	No	1
POR-014 ENSP00000393527 ENST00000447222	H0Y4R2 [Direct mapping] NADPH--cytochrome P450 reductase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process] Show all	725 aa 81.6 kDa	No	0
POR-015 ENSP00000412490 ENST00000439269	E7EMD0 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0016491 [oxidoreductase activity] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process] Show all	418 aa 47.4 kDa	No	0
POR-017 ENSP00000395813 ENST00000453773	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	140 aa 15.8 kDa	No	1
POR-018 ENSP00000390540 ENST00000439963	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	188 aa 21.1 kDa	No	1
POR-019 ENSP00000409881 ENST00000421059	C9JQ78 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process] Show all	39 aa 4.2 kDa	No	0
POR-020 ENSP00000389409 ENST00000432753	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	166 aa 18.7 kDa	No	1
POR-021 ENSP00000399556 ENST00000449920	P16435 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003958 [NADPH-hemoprotein reductase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0016020 [membrane] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0032770 [positive regulation of monooxygenase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] GO:0090346 [cellular organofluorine metabolic process] Show all	62 aa 7.1 kDa	No	1
POR-022 ENSP00000400964 ENST00000426184	C9JU80 [Direct mapping] NADPH--cytochrome P450 reductase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005829 [cytosol] GO:0010181 [FMN binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process] Show all	108 aa 12 kDa	No	0

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