Expression of FGL2 in cancer - Summary - The Human Protein Atlas

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FGL2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FGL2
Gene description	Fibrinogen-like 2
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Karpas-707, LHCN-M2, NB-4, RPTEC TERT1, THP-1, U-937, WM-115)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA021011 , HPA026682
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021011	HPA026682

GENE INFORMATION
Gene name	FGL2 (HGNC Symbol)
Synonyms	pT49, T49
Description	Fibrinogen-like 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	77193371 - 77199826
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127951 (version 83.38)
Entrez gene	10875
UniProt	Q14314 (UniProt - Evidence at protein level)
neXtProt	NX_Q14314
Antibodypedia	FGL2 antibodies

PROTEIN BROWSER

FGL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGL2-001 ENSP00000248598 ENST00000248598	Q14314 [Direct mapping] Fibroleukin A4D1B8 [Target identity:100%; Query identity:100%] Fibrinogen-like 2; cDNA, FLJ93065, Homo sapiens fibrinogen-like 2 (FGL2), mRNA Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005577 [fibrinogen complex] GO:0070062 [extracellular exosome] Show all	439 aa 50.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.