Tissue expression of STEAP4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	STEAP4
Gene description	STEAP family member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	STEAP4 (HGNC Symbol)
Synonyms	FLJ23153, STAMP2, TIARP, TNFAIP9
Description	STEAP family member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Chromosome	7
Cytoband	q21.12
Chromosome location (bp)	88270892 - 88306891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127954 (version 83.38)
Entrez gene	79689
UniProt	Q687X5 (UniProt - Evidence at protein level)
neXtProt	NX_Q687X5
Antibodypedia	STEAP4 antibodies

PROTEIN BROWSER

STEAP4-001	STEAP4-002	STEAP4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STEAP4-001 ENSP00000369419 ENST00000380079	Q687X5 [Direct mapping] Metalloreductase STEAP4 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0045444 [fat cell differentiation] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0097461 [ferric iron import into cell] Show all	459 aa 52 kDa	No	6
STEAP4-002 ENSP00000305545 ENST00000301959	Q687X5 [Direct mapping] Metalloreductase STEAP4 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0045444 [fat cell differentiation] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055072 [iron ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0097461 [ferric iron import into cell] Show all	283 aa 31.3 kDa	No	3
STEAP4-003 ENSP00000394399 ENST00000414498	C9JS50 [Direct mapping] Metalloreductase STEAP4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	339 aa 38.6 kDa	No	4