Expression of CASD1 in cancer - Summary - The Human Protein Atlas

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CASD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CASD1
Gene description	CAS1 domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044404
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044404

GENE INFORMATION
Gene name	CASD1 (HGNC Symbol)
Synonyms	C7orf12, FLJ21213, FLJ21879
Description	CAS1 domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	94509219 - 94557019
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127995 (version 83.38)
Entrez gene	64921
UniProt	Q96PB1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PB1
Antibodypedia	CASD1 antibodies

PROTEIN BROWSER

CASD1-001	CASD1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASD1-001 ENSP00000297273 ENST00000297273	Q96PB1 [Direct mapping] CAS1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	797 aa 91.7 kDa	Yes	>9
CASD1-004 ENSP00000396261 ENST00000447923	C9JDR3 [Direct mapping] CAS1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.