Expression of SPINK2 in cancer - Summary - The Human Protein Atlas

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SPINK2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPINK2
Gene description	Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (lung cancer, testis cancer, thyroid cancer)
HPA (cell line):	Cell line enhanced (Daudi, NB-4, U-266/70)
HPA (normal tissue):	Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in cells epididymis and seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation.
Reliability score	Supported based on 2 antibodies. HPA026813 , CAB020824
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (lung cancer, testis cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026813	CAB020824

GENE INFORMATION
Gene name	SPINK2 (HGNC Symbol)
Synonyms	HUSI-II
Description	Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	56809860 - 56821742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128040 (version 83.38)
Entrez gene	6691
UniProt	P20155 (UniProt - Evidence at protein level)
neXtProt	NX_P20155
Antibodypedia	SPINK2 antibodies

PROTEIN BROWSER

SPINK2-001	SPINK2-002	SPINK2-003	SPINK2-201	SPINK2-202	SPINK2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINK2-001 ENSP00000248701 ENST00000248701	P20155 [Direct mapping] Serine protease inhibitor Kazal-type 2 A0A024RD95 [Target identity:100%; Query identity:100%] Serine peptidase inhibitor, Kazal type 2 (Acrosin-trypsin inhibitor), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] Show all	84 aa 9.3 kDa	Yes	0
SPINK2-002 ENSP00000425961 ENST00000506738	D6RI10 [Direct mapping] Serine protease inhibitor Kazal-type 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0002176 [male germ cell proliferation] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] GO:0007286 [spermatid development] GO:0008584 [male gonad development] GO:0009566 [fertilization] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0072520 [seminiferous tubule development] GO:1900004 [negative regulation of serine-type endopeptidase activity] Show all	134 aa 13.9 kDa	Yes	0
SPINK2-003 ENSP00000423858 ENST00000504762	D6RC51 [Direct mapping] Serine protease inhibitor Kazal-type 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	119 aa 12.5 kDa	Yes	0
SPINK2-201 ENSP00000478284 ENST00000616980	A0A087WU11 [Direct mapping] Serine protease inhibitor Kazal-type 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 8.8 kDa	Yes	0
SPINK2-202 ENSP00000477722 ENST00000618802	A0A087WTA9 [Direct mapping] Serine protease inhibitor Kazal-type 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 14.2 kDa	Yes	0
SPINK2-203 ENSP00000487028 ENST00000631082	A0A0D9SFZ8 [Direct mapping] Serine protease inhibitor Kazal-type 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 10.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.