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GENE INFORMATION
Gene name
YWHAH (HGNC Symbol)
Synonyms
YWHA1
Description
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (HGNC Symbol)
Entrez gene summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Q04917 [Direct mapping] 14-3-3 protein eta A0A024R1K7 [Target identity:100%; Query identity:100%] Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, isoform CRA_b
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002028 [regulation of sodium ion transport] GO:0003779 [actin binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006713 [glucocorticoid catabolic process] GO:0006886 [intracellular protein transport] GO:0006915 [apoptotic process] GO:0007264 [small GTPase mediated signal transduction] GO:0010467 [gene expression] GO:0012501 [programmed cell death] GO:0014704 [intercalated disc] GO:0017080 [sodium channel regulator activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0021762 [substantia nigra development] GO:0030659 [cytoplasmic vesicle membrane] GO:0035259 [glucocorticoid receptor binding] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0044325 [ion channel binding] GO:0045664 [regulation of neuron differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048167 [regulation of synaptic plasticity] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0086010 [membrane depolarization during action potential] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:2000649 [regulation of sodium ion transmembrane transporter activity]