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GNAZ

GENERAL INFORMATION

Gene name

 GNAZ

Gene description

 Guanine nucleotide binding protein (G protein), alpha z polypeptide

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal processes and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA003011
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003011

GENE INFORMATION

Gene name

 GNAZ

Synonyms

Description

 Guanine nucleotide binding protein (G protein), alpha z polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

Chromosome location (bp)

 23070361 - 23125037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128266 (version 83.38)

Entrez gene

 2781

UniProt

 P19086 (UniProt - Evidence at transcript level)

neXtProt

 NX_P19086

Antibodypedia

 GNAZ antibodies

PROTEIN BROWSER
GNAZ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAZ-001
ENSP00000478892
ENST00000615612
P19086 [Direct mapping]
Guanine nucleotide-binding protein G(z) subunit alpha
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005057 [receptor signaling protein activity]
GO:0005525 [GTP binding]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 355 aa
40.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.