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ATF4

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GENERAL INFORMATION

Gene name

 ATF4

Gene description

 Activating transcription factor 4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & microtubule organizing center.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubule organizing center (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB011596
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & microtubule organizing center.

Main location

 Microtubule organizing center (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB011596 A-431 Microtubule organizing center
Cytosol

GENE INFORMATION

Gene name

 ATF4 (HGNC Symbol)

Synonyms

 CREB-2, TAXREB67, TXREB

Description

 Activating transcription factor 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 39519695 - 39522685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128272 (version 83.38)

Entrez gene

 468

UniProt

 P18848 (UniProt - Evidence at protein level)

neXtProt

 NX_P18848

Antibodypedia

 ATF4 antibodies

PROTEIN BROWSER
ATF4-001
ATF4-002
ATF4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATF4-001
ENSP00000384587
ENST00000404241
P18848 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-4
Q96AQ3 [Target identity:100%; Query identity:100%]
ATF4 protein; Activating transcription factor 4 (Tax-responsive enhancer element B67); Activating transcription factor 4 (Tax-responsive enhancer element B67), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006520 [cellular amino acid metabolic process]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032922 [circadian regulation of gene expression]
GO:0034399 [nuclear periphery]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1990037 [Lewy body core]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-002
ENSP00000336790
ENST00000337304
P18848 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-4
Q96AQ3 [Target identity:100%; Query identity:100%]
ATF4 protein; Activating transcription factor 4 (Tax-responsive enhancer element B67); Activating transcription factor 4 (Tax-responsive enhancer element B67), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006520 [cellular amino acid metabolic process]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007623 [circadian rhythm]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032590 [dendrite membrane]
GO:0032922 [circadian regulation of gene expression]
GO:0034198 [cellular response to amino acid starvation]
GO:0034399 [nuclear periphery]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1990037 [Lewy body core]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
GO:1990737 [response to manganese-induced endoplasmic reticulum stress]
Show all
 351 aa
38.6 kDa 		No 0
ATF4-201
ENSP00000379912
ENST00000396680
P18848 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-4
Q96AQ3 [Target identity:100%; Query identity:100%]
ATF4 protein; Activating transcription factor 4 (Tax-responsive enhancer element B67); Activating transcription factor 4 (Tax-responsive enhancer element B67), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006094 [gluconeogenesis]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006520 [cellular amino acid metabolic process]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010628 [positive regulation of gene expression]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032922 [circadian regulation of gene expression]
GO:0034399 [nuclear periphery]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0061395 [positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1990037 [Lewy body core]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990590 [ATF1-ATF4 transcription factor complex]
GO:1990617 [CHOP-ATF4 complex]
Show all
 351 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.