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CDC42EP1

GENERAL INFORMATION

Gene name

 CDC42EP1

Gene description

 CDC42 effector protein (Rho GTPase binding) 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006379
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006379

GENE INFORMATION

Gene name

 CDC42EP1 (HGNC Symbol)

Synonyms

 Borg5, CEP1, MSE55

Description

 CDC42 effector protein (Rho GTPase binding) 1 (HGNC Symbol)

Entrez gene summary

 CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37560447 - 37569405

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128283 (version 83.38)

Entrez gene

 11135

UniProt

 Q00587 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00587

Antibodypedia

 CDC42EP1 antibodies

PROTEIN BROWSER
CDC42EP1-001
CDC42EP1-002
CDC42EP1-003
CDC42EP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP1-001
ENSP00000249014
ENST00000249014
Q00587 [Direct mapping]
Cdc42 effector protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
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 391 aa
40.3 kDa 		No 0
CDC42EP1-002
ENSP00000411682
ENST00000430687
B0QYC8 [Direct mapping]
Cdc42 effector protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
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 70 aa
7.3 kDa 		No 0
CDC42EP1-003
ENSP00000403710
ENST00000434728
B0QYC6 [Direct mapping]
Cdc42 effector protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
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 48 aa
5 kDa 		No 0
CDC42EP1-004
ENSP00000405006
ENST00000415670
B0QYC7 [Direct mapping]
Cdc42 effector protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
Show all
 60 aa
6.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.