Expression of MPST in cancer - Summary - The Human Protein Atlas

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MPST

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPST
Gene description	Mercaptopyruvate sulfurtransferase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA001240
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001240

GENE INFORMATION
Gene name	MPST (HGNC Symbol)
Synonyms	MST, TST2, TUM1
Description	Mercaptopyruvate sulfurtransferase (HGNC Symbol)
Entrez gene summary	This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	37019635 - 37029822
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128309 (version 83.38)
Entrez gene	4357
UniProt	P25325 (UniProt - Evidence at protein level)
neXtProt	NX_P25325
Antibodypedia	MPST antibodies

PROTEIN BROWSER

MPST-001	MPST-002	MPST-003	MPST-004	MPST-005	MPST-006	MPST-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPST-001 ENSP00000411719 ENST00000429360	P25325 [Direct mapping] 3-mercaptopyruvate sulfurtransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0001889 [liver development] GO:0004792 [thiosulfate sulfurtransferase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005829 [cytosol] GO:0009440 [cyanate catabolic process] GO:0009636 [response to toxic substance] GO:0016784 [3-mercaptopyruvate sulfurtransferase activity] GO:0019346 [transsulfuration] GO:0021510 [spinal cord development] GO:0030054 [cell junction] GO:0042802 [identical protein binding] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0070062 [extracellular exosome] GO:0070814 [hydrogen sulfide biosynthetic process] Show all	317 aa 35.2 kDa	No	0
MPST-002 ENSP00000384812 ENST00000401419	P25325 [Direct mapping] 3-mercaptopyruvate sulfurtransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0009440 [cyanate catabolic process] GO:0009636 [response to toxic substance] GO:0016784 [3-mercaptopyruvate sulfurtransferase activity] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0070062 [extracellular exosome] GO:0070814 [hydrogen sulfide biosynthetic process] Show all	297 aa 33.2 kDa	No	0
MPST-003 ENSP00000342333 ENST00000341116	P25325 [Direct mapping] 3-mercaptopyruvate sulfurtransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0009440 [cyanate catabolic process] GO:0009636 [response to toxic substance] GO:0016784 [3-mercaptopyruvate sulfurtransferase activity] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0070062 [extracellular exosome] GO:0070814 [hydrogen sulfide biosynthetic process] Show all	297 aa 33.2 kDa	No	0
MPST-004 ENSP00000383950 ENST00000404802	P25325 [Direct mapping] 3-mercaptopyruvate sulfurtransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0009440 [cyanate catabolic process] GO:0009636 [response to toxic substance] GO:0016784 [3-mercaptopyruvate sulfurtransferase activity] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0070062 [extracellular exosome] GO:0070814 [hydrogen sulfide biosynthetic process] Show all	297 aa 33.2 kDa	No	0
MPST-005 ENSP00000385062 ENST00000404393	B1AH49 [Direct mapping] Sulfurtransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0008152 [metabolic process] Show all	224 aa 25 kDa	No	0
MPST-006 ENSP00000380402 ENST00000397225	P25325 [Direct mapping] 3-mercaptopyruvate sulfurtransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0009440 [cyanate catabolic process] GO:0009636 [response to toxic substance] GO:0016784 [3-mercaptopyruvate sulfurtransferase activity] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0070062 [extracellular exosome] GO:0070814 [hydrogen sulfide biosynthetic process] Show all	297 aa 33.2 kDa	No	0
MPST-201 ENSP00000486251 ENST00000628507	B1AH49 [Direct mapping] Sulfurtransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004792 [thiosulfate sulfurtransferase activity] GO:0008152 [metabolic process] Show all	224 aa 25 kDa	No	0

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