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TST

GENERAL INFORMATION

Gene name

 TST

Gene description

 Thiosulfate sulfurtransferase (rhodanese)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA003044 , HPA003643 , CAB009546
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003044
HPA003643
CAB009546

GENE INFORMATION

Gene name

 TST (HGNC Symbol)

Synonyms

 RDS

Description

 Thiosulfate sulfurtransferase (rhodanese) (HGNC Symbol)

Entrez gene summary

 This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 37010859 - 37020183

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128311 (version 83.38)

Entrez gene

 7263

UniProt

 Q16762 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16762

Antibodypedia

 TST antibodies

PROTEIN BROWSER
TST-001
TST-002
TST-003
TST-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TST-001
ENSP00000249042
ENST00000249042
Q16762 [Direct mapping]
Thiosulfate sulfurtransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004792 [thiosulfate sulfurtransferase activity]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0008097 [5S rRNA binding]
GO:0009440 [cyanate catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035928 [rRNA import into mitochondrion]
GO:0044281 [small molecule metabolic process]
GO:0051029 [rRNA transport]
GO:0070062 [extracellular exosome]
GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase]
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 297 aa
33.4 kDa 		No 0
TST-002
ENSP00000385828
ENST00000403892
Q16762 [Direct mapping]
Thiosulfate sulfurtransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004792 [thiosulfate sulfurtransferase activity]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0008097 [5S rRNA binding]
GO:0009440 [cyanate catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035928 [rRNA import into mitochondrion]
GO:0044281 [small molecule metabolic process]
GO:0051029 [rRNA transport]
GO:0070062 [extracellular exosome]
GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase]
Show all
 297 aa
33.4 kDa 		No 0
TST-003
ENSP00000400764
ENST00000438203
B1AH48 [Direct mapping]
Thiosulfate sulfurtransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004792 [thiosulfate sulfurtransferase activity]
GO:0008152 [metabolic process]
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 124 aa
14.2 kDa 		No 0
TST-201
ENSP00000478739
ENST00000622841
Q16762 [Direct mapping]
Thiosulfate sulfurtransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000098 [sulfur amino acid catabolic process]
GO:0004792 [thiosulfate sulfurtransferase activity]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0008097 [5S rRNA binding]
GO:0009440 [cyanate catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035928 [rRNA import into mitochondrion]
GO:0044281 [small molecule metabolic process]
GO:0051029 [rRNA transport]
GO:0070062 [extracellular exosome]
GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase]
Show all
 297 aa
33.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.