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RAC2

GENERAL INFORMATION

Gene name

 RAC2

Gene description

 Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HL-60, HMC-1, U-87 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 2 antibodies.
HPA047820 , CAB022946
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047820
CAB022946

GENE INFORMATION

Gene name

 RAC2 (HGNC Symbol)

Synonyms

 EN-7

Description

 Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37225261 - 37244448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128340 (version 83.38)

Entrez gene

 5880

UniProt

 P15153 (UniProt - Evidence at protein level)

neXtProt

 NX_P15153

Antibodypedia

 RAC2 antibodies

PROTEIN BROWSER
RAC2-001
RAC2-002
RAC2-003
RAC2-004
RAC2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAC2-001
ENSP00000249071
ENST00000249071
P15153 [Direct mapping]
Ras-related C3 botulinum toxin substrate 2
A0A024R1P2 [Target identity:100%; Query identity:100%]
Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_a
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Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006935 [chemotaxis]
GO:0007015 [actin filament organization]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010810 [regulation of cell-substrate adhesion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019887 [protein kinase regulator activity]
GO:0030027 [lamellipodium]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030670 [phagocytic vesicle membrane]
GO:0042129 [regulation of T cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045453 [bone resorption]
GO:0045859 [regulation of protein kinase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060263 [regulation of respiratory burst]
GO:0060753 [regulation of mast cell chemotaxis]
GO:0070062 [extracellular exosome]
GO:0071593 [lymphocyte aggregation]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:1902622 [regulation of neutrophil migration]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 192 aa
21.4 kDa 		No 0
RAC2-002
ENSP00000385666
ENST00000401529
B1AH79 [Direct mapping]
Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_d
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
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 86 aa
9 kDa 		No 0
RAC2-003
ENSP00000403778
ENST00000441619
B1AH78 [Direct mapping]
Ras-related C3 botulinum toxin substrate 2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
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 166 aa
18.5 kDa 		No 0
RAC2-004
ENSP00000385270
ENST00000406508
B1AH77 [Direct mapping]
Ras-related C3 botulinum toxin substrate 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 148 aa
16.8 kDa 		No 0
RAC2-007
ENSP00000385590
ENST00000405484
B1AH80 [Direct mapping]
Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_c
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 185 aa
20.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.