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LIF

GENERAL INFORMATION

Gene name

 LIF

Gene description

 Leukemia inhibitory factor

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder)
GTEx:Mixed
FANTOM5:Tissue enhanced (appendix, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA018844 , CAB025985
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, gallbladder)

GENE INFORMATION

Gene name

 LIF (HGNC Symbol)

Synonyms

 CDF, DIA, HILDA

Description

 Leukemia inhibitory factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 30240447 - 30246851

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128342 (version 83.38)

Entrez gene

 3976

UniProt

 P15018 (UniProt - Evidence at protein level)

neXtProt

 NX_P15018

Antibodypedia

 LIF antibodies

PROTEIN BROWSER
LIF-001
LIF-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIF-001
ENSP00000249075
ENST00000249075
P15018 [Direct mapping]
Leukemia inhibitory factor
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
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GO:0001135 [transcription factor activity, RNA polymerase II transcription factor recruiting]
GO:0001974 [blood vessel remodeling]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005146 [leukemia inhibitory factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0007566 [embryo implantation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010976 [positive regulation of neuron projection development]
GO:0016525 [negative regulation of angiogenesis]
GO:0019827 [stem cell population maintenance]
GO:0030324 [lung development]
GO:0031100 [organ regeneration]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein]
GO:0042503 [tyrosine phosphorylation of Stat3 protein]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045595 [regulation of cell differentiation]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045835 [negative regulation of meiotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046697 [decidualization]
GO:0046888 [negative regulation of hormone secretion]
GO:0048286 [lung alveolus development]
GO:0048644 [muscle organ morphogenesis]
GO:0048666 [neuron development]
GO:0048708 [astrocyte differentiation]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0048863 [stem cell differentiation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051461 [positive regulation of corticotropin secretion]
GO:0060041 [retina development in camera-type eye]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060290 [transdifferentiation]
GO:0060426 [lung vasculature development]
GO:0060463 [lung lobe morphogenesis]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060708 [spongiotrophoblast differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901676 [positive regulation of histone H3-K27 acetylation]
GO:1903025 [regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
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 202 aa
22 kDa 		Yes 0
LIF-002
ENSP00000384450
ENST00000403987
P15018 [Direct mapping]
Leukemia inhibitory factor
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0001135 [transcription factor activity, RNA polymerase II transcription factor recruiting]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005146 [leukemia inhibitory factor receptor binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046888 [negative regulation of hormone secretion]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901676 [positive regulation of histone H3-K27 acetylation]
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 88 aa
9.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.