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APOBEC3A

GENERAL INFORMATION

Gene name

 APOBEC3A

Gene description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (appendix, bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues, including immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA043237
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043237

GENE INFORMATION

Gene name

 APOBEC3A (HGNC Symbol)

Synonyms

 ARP3, PHRBN

Description

 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38952741 - 38992778

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128383 (version 83.38)

Entrez gene

 200315

UniProt

 P31941 (UniProt - Evidence at protein level)

neXtProt

 NX_P31941

Antibodypedia

 APOBEC3A antibodies

PROTEIN BROWSER
APOBEC3A-001
APOBEC3A-201
APOBEC3A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOBEC3A-001
ENSP00000384359
ENST00000402255
P31941 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3A
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Predicted intracellular proteins
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GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0044356 [clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0047844 [deoxycytidine deaminase activity]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0080111 [DNA demethylation]
Show all
 199 aa
23 kDa 		No 0
APOBEC3A-201
ENSP00000249116
ENST00000249116
P31941 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3A
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Predicted intracellular proteins
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GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0044356 [clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0047844 [deoxycytidine deaminase activity]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0080111 [DNA demethylation]
Show all
 199 aa
23 kDa 		No 0
APOBEC3A-202
ENSP00000481904
ENST00000618553
P31941 [Direct mapping]
DNA dC->dU-editing enzyme APOBEC-3A
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Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0010529 [negative regulation of transposition]
GO:0016787 [hydrolase activity]
GO:0044356 [clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0047844 [deoxycytidine deaminase activity]
GO:0051607 [defense response to virus]
GO:0070383 [DNA cytosine deamination]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0080111 [DNA demethylation]
Show all
 199 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.