Expression of CPA4 in cancer - Summary - The Human Protein Atlas

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CPA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPA4
Gene description	Carboxypeptidase A4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer, head and neck cancer)
HPA (cell line):	Cell line enhanced (LHCN-M2, U-2 OS, U-87 MG)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA021030
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer, head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021030

GENE INFORMATION
Gene name	CPA4 (HGNC Symbol)
Synonyms	CPA3
Description	Carboxypeptidase A4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q32.2
Chromosome location (bp)	130293134 - 130324180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128510 (version 83.38)
Entrez gene	51200
UniProt	Q9UI42 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UI42
Antibodypedia	CPA4 antibodies

PROTEIN BROWSER

CPA4-001	CPA4-003	CPA4-006	CPA4-007	CPA4-009	CPA4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPA4-001 ENSP00000222482 ENST00000222482	Q9UI42 [Direct mapping] Carboxypeptidase A4 A4D1M3 [Target identity:100%; Query identity:100%] Carboxypeptidase A4; Carboxypeptidase A4, isoform CRA_a; cDNA FLJ75086, highly similar to Homo sapiens carboxypeptidase A4, mRNA Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016573 [histone acetylation] Show all	421 aa 47.4 kDa	Yes	0
CPA4-003 ENSP00000419660 ENST00000493259	B7Z5J4 [Direct mapping] Carboxypeptidase A4; cDNA FLJ52025, highly similar to Carboxypeptidase A4 (EC 3.4.17.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	317 aa 35.6 kDa	No	0
CPA4-006 ENSP00000418276 ENST00000486598	C9J7D6 [Direct mapping] Carboxypeptidase A4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.5 kDa	No	0
CPA4-007 ENSP00000418392 ENST00000473956	C9J6N7 [Direct mapping] Carboxypeptidase A4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	177 aa 20.1 kDa	Yes	0
CPA4-009 ENSP00000417255 ENST00000492072	C9J3P4 [Direct mapping] Carboxypeptidase A4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	172 aa 19.7 kDa	Yes	0
CPA4-201 ENSP00000412947 ENST00000445470	Q9UI42 [Direct mapping] Carboxypeptidase A4 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005575 [cellular_component] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016573 [histone acetylation] Show all	388 aa 43.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.