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VGF

GENERAL INFORMATION

Gene name

 VGF

Gene description

 VGF nerve growth factor inducible

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Group enriched (SH-SY5Y, SK-MEL-30, U-2 OS, WM-115)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal cells and neuroendocrine cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA055177 , HPA072505
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and glioma (unfavourable).
Endometrial cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA055177
HPA072505

GENE INFORMATION

Gene name

 VGF (HGNC Symbol)

Synonyms

 SCG7, SgVII

Description

 VGF nerve growth factor inducible (HGNC Symbol)

Entrez gene summary

 This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 101162509 - 101165593

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128564 (version 83.38)

Entrez gene

 7425

UniProt

 O15240 (UniProt - Evidence at protein level)

neXtProt

 NX_O15240

Antibodypedia

 VGF antibodies

PROTEIN BROWSER
VGF-001
VGF-003
VGF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VGF-001
ENSP00000249330
ENST00000249330
O15240 [Direct mapping]
Neurosecretory protein VGF Neuroendocrine regulatory peptide-1 Neuroendocrine regulatory peptide-2 Antimicrobial peptide VGF[554-577]
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001541 [ovarian follicle development]
GO:0002021 [response to dietary excess]
GO:0003674 [molecular_function]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005615 [extracellular space]
GO:0006091 [generation of precursor metabolites and energy]
GO:0008083 [growth factor activity]
GO:0009409 [response to cold]
GO:0019953 [sexual reproduction]
GO:0030073 [insulin secretion]
GO:0030133 [transport vesicle]
GO:0031410 [cytoplasmic vesicle]
GO:0032868 [response to insulin]
GO:0033500 [carbohydrate homeostasis]
GO:0042593 [glucose homeostasis]
GO:0042742 [defense response to bacterium]
GO:0048167 [regulation of synaptic plasticity]
GO:0051591 [response to cAMP]
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 615 aa
67.3 kDa 		Yes 0
VGF-003
ENSP00000400884
ENST00000445482
O15240 [Direct mapping]
Neurosecretory protein VGF Neuroendocrine regulatory peptide-1 Neuroendocrine regulatory peptide-2 Antimicrobial peptide VGF[554-577]
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005179 [hormone activity]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0030133 [transport vesicle]
GO:0031410 [cytoplasmic vesicle]
GO:0033500 [carbohydrate homeostasis]
GO:0042742 [defense response to bacterium]
GO:0048167 [regulation of synaptic plasticity]
GO:0051591 [response to cAMP]
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 615 aa
67.3 kDa 		Yes 0
VGF-201
ENSP00000480817
ENST00000611537
Q05BJ3 [Direct mapping]
Neurosecretory protein VGF; VGF protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005184 [neuropeptide hormone activity]
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 377 aa
39.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.