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CALU

GENERAL INFORMATION

Gene name

 CALU

Gene description

 Calumenin

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA006018
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006018

GENE INFORMATION

Gene name

 CALU

Synonyms

Description

 Calumenin (HGNC Symbol)

Entrez gene summary

 The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Chromosome

 7

Cytoband

 q32.1

Chromosome location (bp)

 128739292 - 128771807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128595 (version 83.38)

Entrez gene

 813

UniProt

 O43852 (UniProt - Evidence at protein level)

neXtProt

 NX_O43852

Antibodypedia

 CALU antibodies

PROTEIN BROWSER
CALU-001
CALU-002
CALU-003
CALU-004
CALU-005
CALU-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CALU-001
ENSP00000249364
ENST00000249364
O43852 [Direct mapping]
Calumenin
Q6IAW5 [Target identity:100%; Query identity:100%]
CALU protein; Calumenin; Calumenin, isoform CRA_b; cDNA, FLJ92797, Homo sapiens calumenin (CALU), mRNA
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0042470 [melanosome]
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 315 aa
37.1 kDa 		Yes 0
CALU-002
ENSP00000408838
ENST00000449187
O43852 [Direct mapping]
Calumenin
A0A024R755 [Target identity:100%; Query identity:100%]
Calumenin, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0042470 [melanosome]
Show all
 315 aa
37.1 kDa 		Yes 0
CALU-003
ENSP00000420381
ENST00000479257
O43852 [Direct mapping]
Calumenin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0042470 [melanosome]
Show all
 323 aa
38.1 kDa 		Yes 0
CALU-004
ENSP00000417973
ENST00000493278
H0Y875 [Direct mapping]
Calumenin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 147 aa
17.3 kDa 		No 0
CALU-005
ENSP00000438248
ENST00000542996
O43852 [Direct mapping]
Calumenin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0004857 [enzyme inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0014012 [peripheral nervous system axon regeneration]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0042470 [melanosome]
GO:0043086 [negative regulation of catalytic activity]
GO:0043231 [intracellular membrane-bounded organelle]
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 323 aa
38.1 kDa 		Yes 0
CALU-006
ENSP00000442110
ENST00000535011
O43852 [Direct mapping]
Calumenin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007596 [blood coagulation]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0042470 [melanosome]
Show all
 224 aa
26.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.