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Most cancer tissues howed weak to moderate cytoplasmic positivity. Lymphomas and several gliomas, cervical, skin and gastric cancers were negative.
GENE INFORMATION
Gene name
SMO (HGNC Symbol)
Synonyms
FZD11, SMOH
Description
Smoothened, frizzled class receptor (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]