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MRPS12

GENERAL INFORMATION

Gene name

 MRPS12

Gene description

 Mitochondrial ribosomal protein S12

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA046775 , HPA050633
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046775
HPA050633

GENE INFORMATION

Gene name

 MRPS12 (HGNC Symbol)

Synonyms

 RPMS12, RPS12, RPSM12

Description

 Mitochondrial ribosomal protein S12 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38930548 - 38933162

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128626 (version 83.38)

Entrez gene

 6183

UniProt

 O15235 (UniProt - Evidence at protein level)

neXtProt

 NX_O15235

Antibodypedia

 MRPS12 antibodies

PROTEIN BROWSER
MRPS12-001
MRPS12-002
MRPS12-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS12-001
ENSP00000308845
ENST00000308018
O15235 [Direct mapping]
28S ribosomal protein S12, mitochondrial
A0A024R0H2 [Target identity:100%; Query identity:100%]
Mitochondrial ribosomal protein S12, isoform CRA_a
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0015935 [small ribosomal subunit]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 138 aa
15.2 kDa 		No 0
MRPS12-002
ENSP00000384952
ENST00000407800
O15235 [Direct mapping]
28S ribosomal protein S12, mitochondrial
A0A024R0H2 [Target identity:100%; Query identity:100%]
Mitochondrial ribosomal protein S12, isoform CRA_a
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0015935 [small ribosomal subunit]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 138 aa
15.2 kDa 		No 0
MRPS12-004
ENSP00000384579
ENST00000402029
O15235 [Direct mapping]
28S ribosomal protein S12, mitochondrial
A0A024R0H2 [Target identity:100%; Query identity:100%]
Mitochondrial ribosomal protein S12, isoform CRA_a
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0015935 [small ribosomal subunit]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 138 aa
15.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.