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Cell line enhanced (EFO-21, RPTEC TERT1, SCLC-21H, SH-SY5Y)
HPA (normal tissue):
Tissue enriched (epididymis)
Protein evidence
Evidence at protein level
ANTIBODY IHC RELIABILITY
Reliability score
Pending cancer tissue analysis.
PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)
PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY
GENE INFORMATION
Gene name
HOXD3 (HGNC Symbol)
Synonyms
HOX1D, HOX4, HOX4A
Description
Homeobox D3 (HGNC Symbol)
Entrez gene summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]