Expression of MTX2 in cancer - Summary - The Human Protein Atlas

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MTX2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MTX2
Gene description	Metaxin 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA031550 , HPA031551 , HPA031552
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031550	HPA031551	HPA031552

GENE INFORMATION
Gene name	MTX2
Synonyms
Description	Metaxin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	176269395 - 176338025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128654 (version 83.38)
Entrez gene	10651
UniProt	O75431 (UniProt - Evidence at protein level)
neXtProt	NX_O75431
Antibodypedia	MTX2 antibodies

PROTEIN BROWSER

MTX2-001	MTX2-004	MTX2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTX2-001 ENSP00000249442 ENST00000249442	O75431 [Direct mapping] Metaxin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] GO:0006839 [mitochondrial transport] GO:0044267 [cellular protein metabolic process] Show all	263 aa 29.8 kDa	Yes	0
MTX2-004 ENSP00000414176 ENST00000443241	C9JNK6 [Direct mapping] Metaxin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		207 aa 23.6 kDa	No	0
MTX2-007 ENSP00000398757 ENST00000452865	C9JAZ1 [Direct mapping] Metaxin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] Show all	229 aa 25.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.