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Most cancers showed weak to moderate cytoplasmic staining. Several gliomas, several cases of breast, cervical, endometrial, skin and testis cancers showed strong positivity. Additional nuclear positivity was observed in a few cases. Several renal cell carcinomas were negative.
Cancer cells displayed cytoplasmic staining with varying intensity. A majority of ovarian, cervical, lung and liver cancers as well as several gliomas, melanomas, pancreatic, stomach and breast cancers showed moderate to strong staining. Remaining cancers were in general weakly stained or negative.
GENE INFORMATION
Gene name
HERC2 (HGNC Symbol)
Synonyms
D15F37S1, jdf2, p528
Description
HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HGNC Symbol)
Entrez gene summary
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]